What are common signs and symptoms of hypercalcemia of malignancy?

Excessive thirst and frequent urination are indeed common signs and symptoms of hypercalcemia of malignancy. In this condition, elevated levels of calcium in the blood can lead to various physiological changes. When calcium levels rise, the kidneys work harder to excrete the excess calcium, which can cause increased urine production, leading to frequent urination. This diuretic effect also contributes to dehydration, prompting excessive thirst as the body attempts to maintain fluid balance.

Additionally, high calcium levels can interfere with normal renal function and lead to greater fluid loss, exacerbating thirst. Such symptoms highlight the body's attempt to manage the imbalance created by hypercalcemia. Understanding these signs is essential for early recognition and management of hypercalcemia, which is critical in patients with malignancies, as timely intervention can prevent more severe complications.